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Notwithstanding their resistance to degradation by DPP-4, exendin-4-based GLP-1 RAs require daily (lixisenatide) or twice daily (exenatide) dosing without further modification

Incretins (GLP-1 receptor agonists and dual/triple agonists) and the liver

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Recent research has shown that semaglutide also plays a significant role in weight loss, revolutionizing the way we approach weight management

While adipose tissue reduction is therapeutically desirable, disproportionate loss of lean mass may lower resting energy expenditure, impair functional capacity, and potentially compromise long-term metabolic durability

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