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Evidence-based comparison of CagriSema (cagrilintide + semaglutide) and semaglutide alone, including REDEFINE trial data and FDA filing status.

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Aims/hypothesis Regulators worldwide are reviewing safety data on glucagon-like peptide-1 receptor agonists (GLP-1RA), following reports by the Icelandic Medicines Agency in July 2023 of suicidal ideation and self-injury (SIS) in individuals taking liraglutide and semaglutide