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The most common adverse events with orforglipron were gastrointestinal in nature and included nausea, diarrhea, constipation, vomiting and dyspepsia

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10.1111/j.1432-1033.1974.tb03580.x 31

3 The contribution of GLP-1 to bariatric surgery Post-prandial GLP-1 concentrations are increased following Roux-en-Y gastric bypass, an observation that has fuelled interest in investigating the role of GLP-1 in mediating weight loss and remission of metabolic derangements following surgery [32-34] All forms of bariatric surgery lead to weight loss to a greater or lesser extent