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Berberine (BBR) exhibits significant anti-diabetic effects by enhancing insulin sensitivity, promoting glycolysis, and inhibiting gluconeogenesis

Clostridium butyricum produces the postbiotic butyrate which stimulates GLP-1

Explore FDA-approved drugs and therapeutic strategies.

Future research should evaluate the impact of GLP- 1 RA on sarcopenia in high-risk patient populations.

Although glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have demonstrated cardiovascular and kidney benefits in the general population with type 2 diabetes mellitus (T2DM), evidence regarding their effects in diabetic KTRs is limited