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other outcomes were cardiovascular and total death, nonfatal myocardial infarction (MI), nonfatal stroke, hospitalization for heart failure (HHF), and renal outcome

3) A shift in framing Mono GLP-1 RA: Reduce glucagon when glucose is high. Tirzepatide: Reduce wrong-time glucagon, preserve right-time glucagon. Practical takeaway When fasting glucose is stubborn despite optimized basal insulin, ask: Is the liver being driven by glucagon more than its being restrained by insulin

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This guide explores prescription options, compounded alternatives, and how genetic and biomarker factors may inform provider conversations about suitability