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[DOI] [PMC free article] [PubMed] [Google Scholar] [201].Baekdal TA, Thomsen M, Kupcova V, Hansen CW, Anderson TW, Pharmacokinetics, Safety, and Tolerability of Oral Semaglutide in Subjects With Hepatic Impairment, Journal of clinical pharmacology, (2018)

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The formulation's GLP-1 pathway contribution comes from trans-resveratrol (Vitis vinifera grape extract), which has been shown in cell-based and clinical research to extend the half-life of endogenous GLP-1 by inhibiting dipeptidyl peptidase-4 (DPP-4) activity, supporting appetite satiation signals and post-meal glycaemic control

Qato, PharmD, MPH, PhD, the Hygeia Centennial Chair and associate professor in the Titus Family Department of Clinical Pharmacy and senior fellow in the Leonard D