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So I started to post on this awesome forum and there was the answer before I even posted

The loose joints are unstable and prone to dislocation and chronic pain

But perfectly positioned to irritate the surrounding cortex and trigger seizures

Before the 1964 Surgeon General warning people generally viewed cigarette smoke as bad, but didn't truly know what kind of poison they were putting into their bodies

When to worry about nicotine poisoning in dogs Always speak to a vet immediately if you suspect your dog has ingested nicotine products, so the risk can be assessed and treatment advice given