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Emerging evidence reported the role of glutamine mediating reductive carboxylation for lipid biosynthesis and also for redox homeostasis in cancer with dysfunctional mitochondria or under hypoxia [34,41-43]

134 By inhibiting cell proliferation and cladogenesis, DHPO exhibits significant antitumor activity in vitro and in vivo

[DOI] [PMC free article] [PubMed] [Google Scholar] 145.Salvucci M, Crawford N, Stott K, Bullman S, Longley DB, Prehn JHM

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Ethics declarations Competing interests Per institutional policy, J.M.F