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(38) conducted a parallel clinical trial assessing the effects of 2 g/day of extended release niacin, 4 g/day of omega-3 fatty acids, a combination of the two, or a respective dual placebo for 16 weeks on plasma lipids and lipoproteins in 56 adults with metabolic syndrome

The protective effect of riboflavin against reperfusion oxidative injury in other organs such as the lung and after cardiac allotransplantation in animal models has also been reported ( Reference Iwanaga, Hasegawa and Hultquist 54 , Reference Seekamp, Hultquist and Till 56 )

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The production of NO from arginine is catalyzed by the enzyme nitric oxide synthase (NOS) via the L-arginine-NO pathway [86]

Org Lett 7:49514954

Sections 3, 4, 6 is summarized in Supplementary Table S2