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The cellular threshold for this fate is determined by a network of parallel antioxidant systems, including the FSP1-CoQ 10 axis that quenches lipid radicals at the membrane [79], and mitochondrial DHODH which regenerates the antioxidant coenzyme QH 2 to suppress mitochondrial-associated ferroptosis [80]
Similar findings have been found by others groups in the Arc, LH, CeA, and the paraventricular nucleus of the thalamus (PVT) in rats subjected to acute and chronic treatment with ethanol (Navarro et al., 2008)
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doi: 10.1186/1477-7819-8-61
Simvastatin prevents dopaminergic neurodegeneration in experimental parkinsonian models: the association with anti-inflammatory responses
It is found in almost every cell and is especially abundant in the liver
