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It supports fat transport into mitochondria and can deliver small, measurable improvements in body weight and fat mass for some people, especially those with overweight or obesity, but it is not a substitute for comprehensive diet, activity, or medically supervised therapies

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Its also thought that isotretinoin can contribute to carnitine deficiency, which can explain why some of our patients experience muscle soreness while on treatment. In a study that investigated the efficacy of reducing isotretinoin-induced myalgias with L-carnitine, 40 of 230 patients who were taking isotretinoin were found to have myalgias