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Biochim Biophys Acta Rev Cancer 1873(1): 188317 Floersheim GL (1971) Antagonistic effects to phalloidin, alpha-amanitin and extracts of Amanita phalloides

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ERT is also potentially limited by reaccumulation of Gb3 in podocytes after dose adjustment during the follow-up period and formation of neutralizing antidrug antibodies after infusion, which reduce the efficacy of ERT by increasing cellular Gb3 deposition and results in harmful clinical outcomes that include progressive loss of renal function 13,14

For in vitro experiments, primary human hepatocytes would be the optimum model closely followed by isolated primary mouse hepatocytes

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