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Description
This is first clinical study demonstrating that a TfR antibody can deliver the enzyme IDS across the BBB into the brain for treatment of Hunter syndrome (mucopolysaccharidosis type II)
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It was further established that the principal pathways are profoundly associated with the PI3K/AKT/MDM2/P53 axis and that the KO of the MDM2 gene markedly weakens the inhibitory action of MLT (149)
Amyloids are also produced by opportunistic gut pathogens such as Pseudomonas spp., Salmonella spp., E
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