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Through injection of -syn preformed fibrils (PFFs) into the striatum of transgenic mice, researchers demonstrated the development of Lewy pathology, nigrostriatal degeneration, and importantly expanded our understanding of cell-to-cell transmission by describing the nature of spread in neuroanatomically connected regions: this provided the first evidence that synthetic -syn PFFs alone can induce the initiation and propagation of -syn pathology in vivo (Luk et al., The evidence of cell-to-cell transmission of pathologic -syn in interconnected brain regions suggests a prion-like mechanism of spread

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The latter is quite stable, and may accumulate during GSH depletion, because GSH is needed to regenerate the selenolate ( pro