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During CF pathogenesis, airway epithelial cells (IB3-1) exposed to ferric ammonium citrate and the ferroptosis inducer erastin demonstrate heightened susceptibility to ferroptosis, compared with CFTR-corrected airway epithelial cells

The apoplastic generation of ROS occurs mainly by enzymes like membrane NADPH-dependent oxidase, cell wall peroxidase or polyamine oxidases (Bolwell et al., 1994)

Polymorphisms in methyl-group metabolism genes and risk of sporadic colorectal cancer with relation to the CpG island methylator phenotype

Reduced NAD+ availability impairs mitochondrial function, suppresses AMPK activation, and downregulates SIRT1-mediated fat oxidation genes