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Approaches like the Mediterranean diet or a low-carb plan focus on reducing processed ingredients and embracing fresh, whole foods
However, the clinical use of natural agonists is limited by poor bioavailability, while synthetic agents like thiazolidinediones are associated with adverse effects, including fluid retention, weight gain, and bone loss
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(58(10)):1166-1175 doi:10.1111/jcpp.12785
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doi: 10.1002/dmrr.987
