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Plasma samples were analyzed, and pharmacokinetic parameters were calculated as described in the Pharmacokinetic Profiling in Rats section

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D/L-glucose competition experiment To measure the competitive effects of CDr17 with D/L-glucose, the media of M1 macrophages differentiated from RAW264.7 cell was changed into DMEM, no glucose (Gibco) with 10% Heat-Inactivated Fetal Bovine Serum (Gibco) and 1% Penicillin Streptomycin (WELGENE), containing 0, 20, 60 mM of D/L-glucose