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Salerno S, Marrale M, Geraci C, Caruso G, Lo Re G, Lo Casto A, Midiri M

Inhibiting toxic aggregation of amyloidogenic proteins: a therapeutic strategy for protein misfolding diseases

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Bioinformatic analysis revealed insulin signaling pathway key molecules being affected in AD patients of which the six kinases, leucine-rich repeat kinase 2 (LRRK2), glycogen synthase kinase 3 beta (GSK3B), AKT serine/threonine kinase 1 (AKT1), epidermal growth factor receptor (EGFR), mitogen-activated protein kinase 1 (MAPK1), and the non-receptor tyrosine kinase FYN, played central roles [56]

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