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The NHS does not set an upper safe limit for B12 because harmful effects from excessive intake have not been definitively established
SAM is also involved in the regulation of tau phosphorylation.51 Moreover, hyperhomocysteinaemia has been shown to be associated with a significant increase in amyloid level and amyloid deposition on cortex and hippocampus in mouse models of AD.53 Overall, vitamin B 12 deficiency may have implications in the neuropathological process of AD
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2007;50(2):2508 Hataya Y, Igarashi S, Yamashita T, and Komatsu Y
