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Antioxidant pretreatment of cells subsequently challenged with PQ had an effect on genes related to growth arrest and senescence as well

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Parthasarathy A, Cross PJ, Dobson RCJ, Adams LE, Savka MA, Hudson AO

The blunted inhibition of hexokinase by glucose-6-phosphate is important not only for allowing high rates of upstream glycolysis and ensuring avid glucose uptake from the extracellular space, but also because glucose-6-phosphate may originate from galactose (through glucose-1-phosphate), glycogen (through glycophagy and/or glycogenolysis), and ribose (through the pentose phosphate pathway forming fructose-6-phosphate), (Fig

In contrast, Ent2 recruitment remains almost constant throughout the event (Fig