n acetylcysteine restores glutathione N-acetyl-l-cysteine averts ferroptosis by fostering peroxidase 4 Protective effects of N-acetylcysteine (NAC)

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Experimental evidence has indicated a substantial increase in nonheme iron accumulation and lipid peroxidation specifically within mitochondria, rather than in the cytoplasm, during myocardial ferroptosis induced by Adriamycin [66]

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Given the limited sample size of our study, we decided to focus specifically on the effect of NAC on the white matter integrity of the fornix bundle, which has been shown to be vulnerable to oxidative stress early in the time course of the illness