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EGFR, epidermal growth factor receptor

Superoxide anion can react quickly with NO in mitochondria to form peroxynitrite (ONOO ) with greater toxicity and pro-apoptotic effect

Best results come from a series of treatments

PLoS ONE 7(11):e48878 Franzini M, Corti A, Martinelli B, Del CA, Emdin M et al (2009) Gamma-glutamyltransferase activity in human atherosclerotic plaquesbiochemical similarities with the circulating enzyme

Yu, RSC Adv

This reprogrammed pathway leads to the production of ATP mainly at substrate level and regeneration of reducing equivalents needed for cells growth, redox balance, and metabolic energy