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Appl Catal B Environ 247:150162

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CCK2R contains the PLXXR motif in ICL2 and has evolved three residue substitutions compared with CCK1R, including S149/A162 ICL2 , N304/K324 6.26 , and N374/H394 8.47 (S149, N304, and N374 in CCK1R

This side effect is well established, but it is often not recognized, according to a case report