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While most of the cysteine for glutathione was derived from exogenous source in nutrient replete culture, serine-derived cysteine may become more important under nutrient-limiting conditions

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Therefore, slight malfunctions arising from overloaded or impaired UPS could lead to over-accumulation of toxic proteins, and eventually cellular death

They applied four solvents, namely, water, 2.5 M solutions of ammonia, ethylenediamine, and pyridine, to synthesize GQDs via PLAL from the pelleted carbon nanoonions using a 532 nm pulsed nanosecond laser