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Plioplys AV, Kasnicka I

Kraft M, Kraft K, Grtner S, Mayerle J, Simon P, Weber E, Schtte K, Stieler J, Koula-Jenik H, Holzhauer P, Grber U, Engel G, Mller C, Feng YS, Aghdassi A, Nitsche C, Malfertheiner P, Patrzyk M, Kohlmann T, Lerch MM

Summary Keywords bioavailability, ellagic acid, ellagitannins, pharmacokinetics, polyphenols, punicalagin, TMA Citation Haarhuis JE, Ahn-Jarvis J, Savva GM, Day-Walsh PE, Ferns C, Hughes S, Triller S, Al-Jaibaji O, Philo M, Acaroz E, Perez-Moral N and Kroon PA (2026) Effect of a polyphenol-rich pomegranate extract on plasma trimethylamine N-oxide levels following an oral carnitine challenge: a randomized controlled crossover trial in healthy adults

It is considered safe as per FDA

The pathomechanisms of AEs occurring after EDs are a result of the individual ingredients of EDs, especially caffeine, taurine, B vitamins, and glucuronolactone

In areas of endemic goiter, changes in thyroid size reflect long-term iodine nutrition (months to years)