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Ibudilast is an inhibitor of phosphodiesterase-3, -4, -10, and -11 and a macrophage migration inhibitory factor, which shows promise as a novel treatment for AUD

[DOI] [PubMed] [Google Scholar] 196.Roeb E., Purucker E., Gartung C., Geier A., Jansen B., Winograd R., Matern S

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The ARE is a cis -acting enhancer sequence that is upstream of many Phase 2 detoxification and antioxidant genes [96] (Figure 5 [97])