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Psychopharmacology (Berl) 109 : 433438 Overmier JB, Seligman MEP

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This persistent pain is attributed to a combination of inflammatory and non-inflammatory mechanisms, with peripheral and central sensitization being implicated as key contributors (Biddle and Sofat 2020)

Poor sleep worsens pain, and pain makes it harder to sleep

Creatine also elevates muscle cell hydration, enabling more amino acids into the muscle that can increase the muscles performance level and duration