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10.1016/j.ijwd.2018.09.004 81 GuarneriF

In addition, we previously showed that upon inhibition of glutamine, cancer cells reduce the amount of GSH by exporting oxidized glutathione (GSSG) out of the cell via GSSG transporters and multiple-drug resistance-associated proteins 57 and by extracellular degradation of GSSG 58

These effects are tissue-specific and influenced by receptor density, co-regulator expression, and intracellular energy status

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GHK-Cu supports the extracellular matrix at a deeper structural level and influences gene expression in ways that retinoids do not
