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10.1016/j.ijwd.2018.09.004 81 GuarneriF

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In addition, we previously showed that upon inhibition of glutamine, cancer cells reduce the amount of GSH by exporting oxidized glutathione (GSSG) out of the cell via GSSG transporters and multiple-drug resistance-associated proteins 57 and by extracellular degradation of GSSG 58

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These effects are tissue-specific and influenced by receptor density, co-regulator expression, and intracellular energy status

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GHK-Cu supports the extracellular matrix at a deeper structural level and influences gene expression in ways that retinoids do not

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