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that is why PARP1 is predominantly localized in the nucleus [7], being responsible for approximately 90% of PAR biosynthesis [14]

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Piperine, an alkaloid from Piper nigrum, has been shown to enhance the bioavailability of curcumin by inhibiting hepatic and intestinal glucuronidation (Shoba et al., 1998)

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Joseph NM, Mosher JT, Buchstaller J, Snider P, McKeever PE, Lim M, et al

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