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This is significant because STAT3 has been shown to be overactivated and overexpressed in PCa

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Studies indicate that long-term metformin use can reduce serum B12 blood test levels by up to 20%, necessitating regular monitoring and preventive B12 supplementation protocols

Functioning as a ligand-activated transcription factor, FXR primarily binds unconjugated bile acids (BAs) like chenodeoxycholic acid (CDCA), forms a heterodimer with the retinoid X receptor (RXR), and translocates to the nucleus

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Glutathione peroxidase primarily catalyzes the conversion of hydroxide ions to water