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Redox homeostasis and cell proliferation are compromised in the absence of Nrf2 A cardinal feature of cells lacking Nrf2 is that their antioxidant capacity is compromised, and this is the justification for it being cast in the role of a master regulator of redox homeostasis

If an agent, such as PPA, that suppressed mitochondrial function was present in vivo but not in vitro , mitochondrial function in the muscle, but not the fibroblast culture, would be more compromised

Abstract Recently, marked therapeutic effects pertaining to the recovery of injured rat spinal cords (1 min compression injury of the sacrocaudal spinal cord (S2-Co1) resulting in tail paralysis) appeared after a single intraperitoneal administration of the stable gastric pentadecapeptide BPC 157 at 10 min post-injury

[DOI] [PubMed] [Google Scholar] 171.Agarwal A., Said T.M

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Peptides were more than 90% pure as judged by HPLC and mass spectrometry