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Description
The acetylation of the sulfur atom prevents the decomposition of GSH and facilitates its absorption through the intestinal wall as is, thus enabling the molecule to pass extensively into the cells
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Glutathione is a required substrate for a family of enzymes called glutathione S-transferases, which conjugate glutathione to reactive compounds including drug metabolites and environmental toxins making them water-soluble for excretion
Glutathione functions as an antioxidant and co-enzyme for chemical reactions that are responsible for healing and protecting cells
Similarly, in the nephrotoxic folic acid-induced acute kidney injury (AKI) mouse model, ferroptosis is the main death pathway of renal tubular cells, and the application of Fer-1 can effectively improve renal function 78
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