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Animals were bleach-synchronized as stated earlier, then grown into day-1-adults and the FA-treatment was performed as in L1 animals, with the exception that the FA concentrations were increased (indicated in the Figure)

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Perturbations in astrocytic lipid handling can drive maladaptive reactive states, promote oxidative stress, impair lysosomal and mitochondrial function and disrupt neuronglia lipid exchange, collectively creating an environment that leads to neurodegeneration

To measure glucose tolerance, mice were fasted on aspen bedding for 6 h and 2 g kg 1 dextrose was administered by i.p

doi: 10.3390/ijms22157772