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Glutamate cysteine ligase catalysis: Dependence on ATP and modifier subunit for regulation of tissue glutathione levels

Elsevier Science Publisher

By restoring key intracellular signaling pathways, enhancing mitochondrial function, and reducing maladaptive inflammatory cycles, peptides may offer orthopaedic surgeons a powerful therapeutic adjunct

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Topical for convenience and localized facial concerns

Although oral therapy with the least toxic of these compounds, glutathione monoethyl ester, did raise erythrocyte and white blood cell glutathione levels in a few affected patients (W Rhead, unpublished results), it also provoked moderate gastrointestinal irritation resulting in vomiting and diarrhea, largely precluding oral therapy with this compound or other related molecules containing free sulfhydryls