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Front Aging 2025;6

In addition, a slew of emerging classes of TXNRD inhibitors have surfaced, encompassing diverse agents such as natural products, metal complexes, and nitro (hetero) aromatic compounds [240]

Vitamin C and E downregulates NADPH oxidase, a major source of ROS in the vascular wall, and upregulates eNOS, thus decreasing oxidative stress and lowing BP [95]

Liang, Y., Alharthi, A.S., Bucktrout, R., Elolimy, A.A., Lopreiato, V., Martinez-Corts, I., Xu, C., Fernandez, C., Trevisi, E

By reducing oxidative stress, glutathione helps maintain a healthier and brighter complexion

Two-site Substrate Recognition Model for the Keap1-Nrf2 System: a Hinge and Latch Mechanism
