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In particular, taurine has been documented to be a direct liver X receptor (LXR-) ligand, which modulates the expression of genes implicated in reverse cholesterol transport in macrophages, this way compromising cholesterol to lipid accumulation without increasing hepatic fatty acid synthesis (224)

Hydroxyurea increases HbF level, which often results in fewer painful episodes, hospital admissions, and transfusions

Ionophores A class of compounds that reversibly bind ions and facilitate their transport across cell membranes

Pharmacol., 2004, 67 (6), 11391151

however, the rate constant of the reaction of hydroquinones with H 2 O 2 is rather low, approximately 10 3 M 1 s 1 10 4 M 1 s 1 in the phosphate buffer [88]

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