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Para NAD+ y sus precursores existe un cuerpo consolidado que vincula la disponibilidad de esta coenzima con la actividad de sirtuinas, la reparacin del ADN mediada por PARP y la eficiencia de la OXPHOS

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The latter is believed to occur from those spRNAs that are associated with leftover histone protein in the nucleus and are potentiated for transcription (Miller, 2007)
