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Cardiovascular health represents one of the most studied areas

For the mixed spheroids, LEC were collected 48 h after transfection and labeled with cell membrane labeling lipophilic dyes CellVue Jade and CellVue NIR780 (88-0876-16 and 88-0875-16 respectively, Thermo Fisher Scientific)

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10.1158/1078-0432.CCR-11-3281 84 RennardS

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It is well known that p21 cip1 is a cyclin-dependent kinase inhibitor that directly inhibits the activity of cyclin E/CDK2 and cyclin D/CDK4/6 complexes, thus inhibiting Rb phosphorylation