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LIPIDS ARE TRANSPORTED IN THE PLASMA AS LIPOPROTEINS Four Major Lipid Classes Are Present in Lipoproteins Plasma lipids consist of triacylglycerols (16%), phospholipids (30%), cholesterol (14%), and cholesteryl esters (36%) and a much smaller fraction of unesterified long-chain fatty acids (free fatty acids or FFA) (4%)

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32,44,45 While SIRT6 is widely recognized as a tumor suppressor and lipid reducer in certain contextssuch as in the liver, where it suppresses lipogenic pathways 46 or promotes fatty acid -oxidation, 32 and in cardiomyocytes, where it inhibits PPAR-mediated fatty acid uptake 47 emerging evidence underscores its functional diversity

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Specifically, nhr-49 stimulates the consumption of fat mainly by promoting the expression of fatty acid -oxidation-related genes, such as acyl-CoA synthetase gene acs-2 , mitochondrial -oxidation trifunctional enzyme gene ech-1 , and carnitine palmitoyl transferase gene F09F3.9