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(2016) Randomized, placebo-controlled trial of methyl B12 for children with autism

We list it as our high-potency pick for two specific scenarios: anyone with documented deficiency working to replete liver stores, and anyone whose absorption is significantly compromised (long-term metformin + PPI combination, post-bariatric surgery, atrophic gastritis on biopsy)

Then using a H 2 O 2 -induced senescent TM3 Leydig cell model, we found that FOXO4 maintains the viability of senescent Leydig cells and that the FOXO4 blocker FOXO4-DRI induces apoptosis in these senescent cells

2025 Apr Matthew J

IGF-1 LR3 works more subtly, optimizing natural processes rather than overriding them completely
