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Reprofiled drug targets ancient protozoans
PMID: 17409429
doi: 10.1016/j.pnmrs.2017.05.001 32 DingZ.-S.TianS.-P.ZhengX.-L.ZhouZ.-W.XuY
P-glycoprotein inhibitor valspodar (PSC-833) increases the intracellular concentrations of daunorubicin in vivo in patients with P-glycoprotein-positive acute myeloid leukemia

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In detoxification research, glutathione serves as the substrate for glutathione S-transferases (GSTs) a large superfamily of enzymes that conjugate GSH to electrophilic xenobiotics and reactive metabolites, initiating their excretion via the mercapturic acid pathway
