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Functional impairment of monocyte-derived dendritic cells in patients with severe chronic kidney disease

However, the inherent biosafety, large-scale production processes, and cost-effectiveness of these complex systems are practical issues that must be resolved before they can enter clinical practice

Eighteen rats were randomly allocated into three groups and received different treatments: sham group (sham operation, n = 6)

BHB, one of the KBs, can also enhance oxidative brain metabolism, resulting in the production of gamma-aminobutyric acid (GABA) (27), GABA B activation (24), the induction of synaptic recycling of glutamate loaded vesicles (24, 28), activation of K ATP (18), activation of two-pore domain potassium channels (K2P) (20), and the decrease of acid-sensing channels (ASICs) (29), thereby dampening neuronal excitability (20)