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Despite the enormous success of the Hib-conjugate vaccine in preventing invasive infections caused by capsular type b H.influenzae , it has no effect on NTHi because these strains lacks the type b capsule (the vaccine target) (Smith-Vaughan et al., 2014)

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[PubMed] [Google Scholar] 34.LaRowe SD, Mardikian P, Malcolm R, et al

It can be improved within 1-2 weeks, whereas some chronic diseases, such as arthritis or tissue regeneration, can require 4-6 weeks or more