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Concepts and Mechanisms Underlying Chemotherapy Induced Immunogenic Cell Death: Impact on Clinical Studies and

The desulfhydration process of homocysteine by cystathionine--synthase (CBS) needs SAM to act as an allosteric activator, and produces cysteine through cystathionine generating hydrogen sulfide (H 2 S), a molecule recognized for its anti-inflammatory and antioxidant effects

J Clin Med 8:1815

Folate-sodium alginate-cholesterol nanoparticles delivering doxorubicin and metformin achieved targeted accumulation and induced various forms of programmed cell death, including necroptosis, apoptosis, and pyroptosis in xenograft melanoma tumors (Song et al., 2021)

Cell debris was removed by centrifugation at 4,400 g at 4 C for 30 min, and the clarified cell lysate was directly used for biocatalytic reactions

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