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PNAS DOI:10.1073/pnas.2505412123 Abstract Molecular underpinnings of induced degenerative heterogeneity in the retinal pigment epithelium Cigarette smoking induces epigenetic changes that can cause degenerative heterogeneity with aging and disease

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In contrast, other cells of the body suffered only indirect damage, as tobacco smoking seems to affect key mechanisms in these cells that in turn mutate DNA. Professor David Phillips An author on the paper and Professor of Environmental Carcinogenesis at Kings College London The study revealed at least five distinct processes of DNA damage due to cigarette smoking

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