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In this experiment Schwarzlnder and co-workers (2009) demonstrated a redox perturbation in the mitochondria after Cd exposure with important effects on redox signaling

1e, Chac1 was stabilized by MG132 treatment, whereas treatments with Baf, CMA or ALLN showed small effects

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140 Thus, cysteine contributes to the inhibition of ferroptosis both as a component of glutathione, which facilitates the scavenging of lipid peroxides by the phospholipid hydroperoxidase glutathione peroxidase 4 (GPX4), and as a substrate of NFS1