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Taken together, while several interventions show biological plausibility and early clinical signals, PRP is the only modality in our reference set that consistently approaches higher-tier evidence under the OCEBM 2011 framework, whereas the remaining modalities should be interpreted with moderate-to-low confidence pending larger, methodologically standardized randomized trials with longer follow-up and stronger safety reporting

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Chindo BA, Howes MJR, Abuhamdah S, Yakubu MI, Ayuba GI, Battison A, Chazot PL (2021) New insights into the anticonvulsant effects of essential oil from Melissa officinalis L

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This means that even at a LOD of 1 fM and assuming that all 10 5 target molecules reach the detecting surface and bind to a receptor, there is a binding event involving one recognition element for every ten million (10 7 ) populating the detecting interface

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