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The reduced PPIXpeptide (compound 1 ) and oxidized version with both Met residues oxidized to MetO (compound 2 ) were synthesized by using standard, microwave-assisted Fmoc solid-phase peptide synthesis, followed by an on-resin coupling of PPIX and purification through high-performance liquid chromatography (HPLC) after cleavage (Supplementary Figs

Since these ADRs can be hard to distinguish from the clinical picture associated with sarcoidosis, they are rather underestimated as serious causative agents of these drug-induced (DI) conditions

This is particularly important for patients suffering from severe spinal cord injuries, where conventional treatments often offer limited benefits

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Insulin-like growth factor (IGF) signaling plays an important autocrine, paracrine and endocrine role in growth promotion involving various tissues and organs

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