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As the presence of OXGR1 mRNA in human brain cells has been reported [75], itaconate might also act as extracellular signaling molecule in brain

Temporary cramping, urgency, mild rectal irritation, or lightheadedness can occurpause and report symptoms

Hypercalcemia can be very discomforting as it causes stomach upset, vomiting, weakness, and frequent urination

reported that Shaoyao-Gancao Decoction (SGD), commonly used to treat multiple gynecological disorders such as dysmenorrhea, adenomyosis, and PCOS, modulated gut microbiota composition, and alleviated chronic low-grade inflammation by downregulating cytokines including IL-18, IL-1, IL-6, and TNF- in both serum and ovarian mRNA expression in PCOS rats (238)

M., & Jiang, J

Supplemented and endogenous antioxidants collaborate to neutralise and eliminate free radicals
