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Key research priorities include pediatric otoprotective trials, validated cochlear injury biomarkers, and implementation strategies for diverse healthcare settings

Activation of AMPK Signaling Pathway A significant cellular pathway influenced by MOTS-c is the AMP-activated protein kinase (AMPK) signaling pathway

For instance, it has been shown that some MB cell lines including DAOY (SHH), ONS-76 (SHH), D458 (Group-3), HD-MB03 (Group-3), CHLA-01-MED (Group-4) and CHLA-01R-MED (Group-4) showed the growth and metastatization features of MB tumors of each subgroup they belong only when they were cultured in a 3D hyaluronic acid hydrogels but not when cultured in conventional conditions as adherent cells (113)

Trends Immunol (2012) 33(4):16873
